Endocrine Abstracts

HPA axis that plays important controlling and modulating functions in organism is also linked with insulin resistance and weight control. The number of evidences linking cortisol secretion with obesity and other metabolic complication increase, but still there is a lack of definitive results. Therefore the aim of our study was to compare adrenal function parameters between high and normal insulin resistant overweight and obese women. This retrospective analysis was performed o...

3-Iodothyronamine (3-T1AM) is an endogenous metabolite of thyroid hormone (TH) for which was shown to have various effects. One of the effects is body temperature decline, which may be related with menthol receptor TRPM8. Normally, this ion channel is expressed in neuronal tissue, where it has a nociceptive role. Functional TRPM8 expression has also been shown in non-neuronal cells of the eye such as corneal and conjunctival epithelial cells, corneal endothelial cel...

We present two case reports of patients who were diagnosed with hyperparathyroidism based on a parathyroid gland adenoma (PTA). The pathological parathyroid tissue was precisely localised by ultrasonography and scintigraphy before the surgery. In both cases all four parathyroid glands were revised by the surgeon resulting in an operation extension. Another parathyroid gland was removed and histologically confirmed as PTA. This surgeon’s approach was beneficial for the pat...

Introduction: DHEA is a well-known neurosteroid. Its plasmatic level is reduced with ageing in most individuals. A non-negligible portion of DHEA is hydroxylated at C7 and C16 to 7α-, 7β- and 16α- and 16β-hydroxyderivatives. A part of the antiglucocorticoid function of DHEA has been described to its 7-oxygenated metabolites, namely to 7α-hydroxy-DHEA. Due its anti-glucocoticoid action it is also considered a factor in fat deposition processes. Thus, we...

Introduction: Whereas the daily profiles of the main steroid hormones are well known, minor differences in the course of their levels related to defined and standardised food intake were studied rarely.Methods: Eight women (mean age 29.48±2.99 years, mean BMI 21.3±1.3 kg/m2) in follicular phase of menstrual cycle were examined. The levels of C-peptide, glucose, LH, FSH, SHBG, cortisol, testosterone, dihydrotestosterone, progesterone,...

Introduction: Autoimmune polyglandular syndrome type 2 (APS type 2) is co-occurrence of primary adrenal insufficiency (Addison disease) and autoimmune thyroid disease – most commonly Hashimoto thyroiditis (Schmidt syndrome). If it is associated with type 1 diabetes mellitus it is known as Carpenter syndrome. We present clinical pictures of two 33-year-old patients (born in 1980) diagnosed with APS type 2 manifested as Carpenter syndrome to emphasize different courses of t...

Introduction: The severe course of hyperandrogenism during the menopausal transition requires the exclusion of androgen-secreting tumors.Case report: A 60-year-old postmenopausal woman was referred to the Department of Endocrinology with a 3-year history of progressive development of hyperandrogenism with virilization (severe hirsutism, frontal balding, deepening of voice, increased muscle mass, and secondary polycythemia).Hormonal...

Background: TSH secreting pituitary adenomas represent small proportion of functional pituitary tumours presenting as hyperthyroidism with elevated thyroid hormone levels and inappropriately normal or increased TSH concentration. They are ≥1 cm in size and quite aggressive with tendency to relapse following transphenoidal adenomectomy (TSA). Surgical resection remains gold standard in their definitive treatment while pharmacotherapy with long-acting somatostatin analogue...

Introduction: Studies suggest that disturbed thyroid hormones (TH) homeostasis may lead to increased cancer risk. However, the exact role of TH in cancerogenesis is unknown. We have previously identified 15 genes linked with TH signaling in 7 cancer types and 10.967 cancer patients. Here, we investigated the influence of hypothyroidism on the expression of these 15 genes in rat tissues/organs from which the previously identified, TH-related cancer types originate.<p class=...

Introduction: With the wider availability of imaging techniques there is an increasing number of newly diagnosed, accidentally found pathological formations in the adrenal glands known as adrenal incidentaloma (AI). Currently, the professional consensus is that hormonally active incidentalomas and those suspicious of malignancy should be indicated for surgery.Methods: In our retrospective study, we analyzed data of 141 patients with a total of 160 AIs, w...